Publications
Publications
1. Zhang X.#, Carroll W.#, Nguyen T.B.#, Nguyen T.H., Yang Z., Ma M.L., Huang X.W., Hills A., Guo H., Karnik R., Blatt M.R.*, Zhang P. *. GORK K+ channel structure and gating vital to informing stomatal engineering. Nat Commun. 2025. (accepted).
2. Wang J.P.#, Du B.Y.#, Zhang X.#, Qu X.M., Yang Y., Yang Z., Wang Y.F.*, Zhang P.*. Cryo-EM structures of Arabidopsis CNGC1 and CNGC5 reveal molecular mechanisms underlying gating and calcium selectivity. Nat Plants. 2025b. doi:10.1038/s41477-025-01923-z
3. Fang S.#, Yang Y.#, Zhang X.#, Yang Z., Zhang M.H., Zhao Y., Zhang C.S., Yu F., Wang Y.F.*, Zhang P.*. Structural mechanism underlying PHO1;H1 mediated phosphate transport in Arabidopsis. Nat Plants. 2025a. doi:10.1038/s41477-024-01895-6.
4. An N.#, Huang X.W.#, Yang Z., Zhang M.H., Ma M.L., Yu Fang., Jing L.Y., Du B.Y., Wang Y.F., Zhang X.*, Zhang P.*. Cryo-EM structure and molecular mechanism of the jasmonic acid transporter ABCG16. Nat Plants. 2024. 10: 2052-2061. doi:10.1038/s41477-024-01839-0.
5. Huang X.W.#, Zhang X.#, An N., Zhang M.H., Ma M.L., Yang Y., Jing L.Y., Wang Y.F., Chen Z.G.*, Zhang P.*. Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25. Nat Plants. 2023.9(10):1709-1719. doi:10.1038/s41477-023-01509-7
6. Yang Z.#, Zhang X.#, Ye S.W.#, Zheng J.T., Huang X.W., Yu F., Chen Z.G.*, Cai S.Q.*, Zhang P.*. Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun. 2023. 14(1): 4879. doi: 10.1038/s41467-023-40624-z
7. Ha Y.H. #, Zhang X. #, Liu Y.Q., Ma M.L., Huang X.W., Liu H.T., Zhang P.*. Cryo-EM structure of the CRY2 and CIB1 fragment complex provides insights into CIB1-mediated photosignaling. Plant Commun. 2023. 4(2):100475. doi: 10.1016/j.xplc.2022.100475.
8. Fang S. #, Huang X.W.#, Zhang X.#,*, Zhang M.H., Hao YH, Guo H., Liu L.N., Yu F., Zhang P.*. Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA. Proc Natl Acad Sci U S A. 2021.118 (22) e2101632118. doi: 10.1073/pnas.2101632118.
9. Shao K. #, Zhang X. #, Li X. #, Hao Y.H., Huang X.W., Ma M.L., Zhang M.H., Yu F., Liu H.T.*, Zhang P.*. The oligomeric structures of plant cryptochromes. Nat. Struct. Mol. Biol. 2020. 27(5): 480-488. doi: 10.1038/s41594-020-0420-x.（Views and News in NSMB）
10. Li J.X.#, Yu F. #, Guo H., Xiong R.X., Zhang W.J., He F.Y., Zhang M.H., Zhang P.*. Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Res. 2020.30(1): 61-69. doi: 10.1038/s41422-019-0244-6.
11. Wang C.C., Sun B., Zhang X., Huang X.W., Zhang M.H., Guo H., Chen X., Huang F., Chen T.Y., Mi H.L., Yu F., Liu L.N., Zhang P.*. Structural mechanism of the active bicarbonate transporter from cyanobacteria. Nat Plants. 2019. 5(11):1184-1193. doi: 10.1038/s41477-019-0538-1.
12. Li J.X. #, Wang C.Y. # , Yang G.H., Sun Z., Guo H., Shao K., Gu Y., Jiang W.H.*, Zhang P.*. Molecular mechanism of environmental D-xylose perception by a XylFII-LytS complex in bacteria. Proc Natl Acad Sci U S A. 2017. 114(31):8235-8240. doi: 10.1073/pnas.1620183114.
13. Bao Z.H. #, Qi X.F. #, Hong S., Xu K., He F.Y., Zhang M.H., Chen J.G., Chao D.Y., Zhao W., Li D.F., Wang JW. *, Zhang P.*. Structure and mechanism of a group‐I cobalt energy coupling factor transporter. Cell Res. 2017. 27(5):675-687. doi: 10.1038/cr.2017.38.
14. Qi X.F., Lin W., Ma M.L., Wang C.Y., He Y., He N.S., Gao J., Zhou H., Xiao Y.L., Wang Y., and Zhang P.*. Structural basis of rifampin inactivation by rifampin phosphotransferase. Proc Natl Acad Sci U S A. 2016. 113 (14) 3803-3808. doi: 10.1073/pnas.1523614113.
15. Wang C. #, Chen Q. #, Fan D., Li J., Wang G.*, and Zhang P.*. Structural analyses of short-chain prenyltransferases identify an evolutionarily conserved GFPPS clade in Brassicaceae plants. Mol Plant. 2016. 9(2):195-204. doi: 10.1016/j.molp.2015.10.010. (Cover & Highlight)
16. Zhao Q. #, Wang C.C. #, Wang C.Y., Guo H., Bao Z.H., Zhang M.H., Zhang P.*. Structures of FolT at substrate-bound and substrate-released conformations reveal a gating mechanism of ECF transporters. Nat Commun. 2015. 6:7661. doi: 10.1038/ncomms8661.
17. Yu F. #, He F.Y. #, Yao H.Y., Wang C.Y., Wang J.C., Li J.X., Qi X.F., Xue H.W.*, Ding J.P.*, Zhang P.*. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. EMBO Rep. 2015. 16 (7). 813-823. doi: 10.15252/embr.201540137. (Recommended by Faculty 1000, Biology)
18. Zhang M.H.#, Bao Z.H.#, Zhao Q., Guo H., Xu K., Wang C.C., Zhang P.*. Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters. Proc Natl Acad Sci U S A. 2014. 111(52):18560-18565. doi: 10.1073/pnas.1412246112.
19. Xu K. #, Zhang M.H. #, Zhao Q. #, Yu F. #, Guo H., Wang C.Y., He F.Y., Ding J.P., Zhang P.*. Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature. 2013. 497(7448):268-271. doi: 10.1038/nature12046. (Recommended by Faculty 1000, Biology; Highlighted by Nature China.)
20. Zhang P., Wang J.W. and Shi Y. Structure and mechanism of the S component of a bacterial ECF transporter. Nature. 2010; 468(7324): 717-720. doi: 10.1038/nature09488. (Recommended by Faculty 1000, Biology)
2. Wang J.P.#, Du B.Y.#, Zhang X.#, Qu X.M., Yang Y., Yang Z., Wang Y.F.*, Zhang P.*. Cryo-EM structures of Arabidopsis CNGC1 and CNGC5 reveal molecular mechanisms underlying gating and calcium selectivity. Nat Plants. 2025b. doi:10.1038/s41477-025-01923-z
3. Fang S.#, Yang Y.#, Zhang X.#, Yang Z., Zhang M.H., Zhao Y., Zhang C.S., Yu F., Wang Y.F.*, Zhang P.*. Structural mechanism underlying PHO1;H1 mediated phosphate transport in Arabidopsis. Nat Plants. 2025a. doi:10.1038/s41477-024-01895-6.
4. An N.#, Huang X.W.#, Yang Z., Zhang M.H., Ma M.L., Yu Fang., Jing L.Y., Du B.Y., Wang Y.F., Zhang X.*, Zhang P.*. Cryo-EM structure and molecular mechanism of the jasmonic acid transporter ABCG16. Nat Plants. 2024. 10: 2052-2061. doi:10.1038/s41477-024-01839-0.
5. Huang X.W.#, Zhang X.#, An N., Zhang M.H., Ma M.L., Yang Y., Jing L.Y., Wang Y.F., Chen Z.G.*, Zhang P.*. Cryo-EM structure and molecular mechanism of abscisic acid transporter ABCG25. Nat Plants. 2023.9(10):1709-1719. doi:10.1038/s41477-023-01509-7
6. Yang Z.#, Zhang X.#, Ye S.W.#, Zheng J.T., Huang X.W., Yu F., Chen Z.G.*, Cai S.Q.*, Zhang P.*. Molecular mechanism underlying regulation of Arabidopsis CLCa transporter by nucleotides and phospholipids. Nat Commun. 2023. 14(1): 4879. doi: 10.1038/s41467-023-40624-z
7. Ha Y.H. #, Zhang X. #, Liu Y.Q., Ma M.L., Huang X.W., Liu H.T., Zhang P.*. Cryo-EM structure of the CRY2 and CIB1 fragment complex provides insights into CIB1-mediated photosignaling. Plant Commun. 2023. 4(2):100475. doi: 10.1016/j.xplc.2022.100475.
8. Fang S. #, Huang X.W.#, Zhang X.#,*, Zhang M.H., Hao YH, Guo H., Liu L.N., Yu F., Zhang P.*. Molecular mechanism underlying transport and allosteric inhibition of bicarbonate transporter SbtA. Proc Natl Acad Sci U S A. 2021.118 (22) e2101632118. doi: 10.1073/pnas.2101632118.
9. Shao K. #, Zhang X. #, Li X. #, Hao Y.H., Huang X.W., Ma M.L., Zhang M.H., Yu F., Liu H.T.*, Zhang P.*. The oligomeric structures of plant cryptochromes. Nat. Struct. Mol. Biol. 2020. 27(5): 480-488. doi: 10.1038/s41594-020-0420-x.（Views and News in NSMB）
10. Li J.X.#, Yu F. #, Guo H., Xiong R.X., Zhang W.J., He F.Y., Zhang M.H., Zhang P.*. Crystal structure of plant PLDα1 reveals catalytic and regulatory mechanisms of eukaryotic phospholipase D. Cell Res. 2020.30(1): 61-69. doi: 10.1038/s41422-019-0244-6.
11. Wang C.C., Sun B., Zhang X., Huang X.W., Zhang M.H., Guo H., Chen X., Huang F., Chen T.Y., Mi H.L., Yu F., Liu L.N., Zhang P.*. Structural mechanism of the active bicarbonate transporter from cyanobacteria. Nat Plants. 2019. 5(11):1184-1193. doi: 10.1038/s41477-019-0538-1.
12. Li J.X. #, Wang C.Y. # , Yang G.H., Sun Z., Guo H., Shao K., Gu Y., Jiang W.H.*, Zhang P.*. Molecular mechanism of environmental D-xylose perception by a XylFII-LytS complex in bacteria. Proc Natl Acad Sci U S A. 2017. 114(31):8235-8240. doi: 10.1073/pnas.1620183114.
13. Bao Z.H. #, Qi X.F. #, Hong S., Xu K., He F.Y., Zhang M.H., Chen J.G., Chao D.Y., Zhao W., Li D.F., Wang JW. *, Zhang P.*. Structure and mechanism of a group‐I cobalt energy coupling factor transporter. Cell Res. 2017. 27(5):675-687. doi: 10.1038/cr.2017.38.
14. Qi X.F., Lin W., Ma M.L., Wang C.Y., He Y., He N.S., Gao J., Zhou H., Xiao Y.L., Wang Y., and Zhang P.*. Structural basis of rifampin inactivation by rifampin phosphotransferase. Proc Natl Acad Sci U S A. 2016. 113 (14) 3803-3808. doi: 10.1073/pnas.1523614113.
15. Wang C. #, Chen Q. #, Fan D., Li J., Wang G.*, and Zhang P.*. Structural analyses of short-chain prenyltransferases identify an evolutionarily conserved GFPPS clade in Brassicaceae plants. Mol Plant. 2016. 9(2):195-204. doi: 10.1016/j.molp.2015.10.010. (Cover & Highlight)
16. Zhao Q. #, Wang C.C. #, Wang C.Y., Guo H., Bao Z.H., Zhang M.H., Zhang P.*. Structures of FolT at substrate-bound and substrate-released conformations reveal a gating mechanism of ECF transporters. Nat Commun. 2015. 6:7661. doi: 10.1038/ncomms8661.
17. Yu F. #, He F.Y. #, Yao H.Y., Wang C.Y., Wang J.C., Li J.X., Qi X.F., Xue H.W.*, Ding J.P.*, Zhang P.*. Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex. EMBO Rep. 2015. 16 (7). 813-823. doi: 10.15252/embr.201540137. (Recommended by Faculty 1000, Biology)
18. Zhang M.H.#, Bao Z.H.#, Zhao Q., Guo H., Xu K., Wang C.C., Zhang P.*. Structure of a pantothenate transporter and implications for ECF module sharing and energy coupling of group II ECF transporters. Proc Natl Acad Sci U S A. 2014. 111(52):18560-18565. doi: 10.1073/pnas.1412246112.
19. Xu K. #, Zhang M.H. #, Zhao Q. #, Yu F. #, Guo H., Wang C.Y., He F.Y., Ding J.P., Zhang P.*. Crystal structure of a folate energy-coupling factor transporter from Lactobacillus brevis. Nature. 2013. 497(7448):268-271. doi: 10.1038/nature12046. (Recommended by Faculty 1000, Biology; Highlighted by Nature China.)
20. Zhang P., Wang J.W. and Shi Y. Structure and mechanism of the S component of a bacterial ECF transporter. Nature. 2010; 468(7324): 717-720. doi: 10.1038/nature09488. (Recommended by Faculty 1000, Biology)